open.substack.com/pub/rozenberg/p/ag-says-pm-will-fight-jew-hatred
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Flotilla prisoners abused by Israel
Attorney general and justice minister say attacks are putting lives in danger and threatening UK prosperity.
— Read on www.lawgazette.co.uk/news/labour-conference-tory-attacks-putting-judges-at-personal-risk/5124600.article
NHS issues omeprazole warning
— Read on www.manchestereveningnews.co.uk/news/health/nhs-issues-omeprazole-warning-those-32563150
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Your Party finances
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Corbyn recognises Israel
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Starmer and Herzog
seeking the arrest of Israeli President Isaac Herzog for grave breaches of the Geneva Conventions
— Read on www.hindrajabfoundation.org/perpetrators/herzog-complaint-in-uk-police-fail-to-act-and-cps-issues-weak-rejection-on-purported-evidential-grounds
Hi My name is Keith aged 59
i was diagnosed with PD 9 months ago and have been researching the connection with PD and TCE Trycoethelene Decreasing solvents eg Genklene / Inhibisol which i used at Cummins Diesel engines…
— Read on forum.parkinsons.org.uk/t/pd-and-contact-with-tce-genklene-inhibisol/16772
e: Holmes v Poeton Holdings Limited [2023] EWCA Civ 1377
— Read on www.guildhallchambers.co.uk/2023/12/14/case-law-update-holmes-v-poeton-holdings-limited-2023-ewca-civ-1377/
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Man attacked by leopard in Surrey
Understanding and neutralising covid-19 misinformation and disinformation | The BMJ
— Read on www.bmj.com/content/379/bmj-2022-070331
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Censored documents re: Israel WWII
Surgeon carried out amputations but had a secret sexual fetish for body modification.
— Read on www.lawgazette.co.uk/news/former-patients-of-disgraced-amputee-surgeon-demand-clarity/5124371.article
Ahead of the first World Lake Day, which is 27 August, here’s a closer look at the biggest threats to the world’s lakes – and what can be done about them.
— Read on www.unep.org/news-and-stories/story/lakes-around-world-are-decline-heres-why-and-what-can-be-done-about-it
Britain sent over 500 spy flights to Gaza: AOAV study reveals the scale of British intelligence gathering above Gaza, raising fears of complicity in Israeli war crimes
— Read on aoav.org.uk/2025/britain-sent-over-500-spy-flights-to-gaza-aoav-study-reveals-the-scale-of-british-intelligence-gathering-above-gaza-raising-fears-of-complicity-in-israeli-war-crimes/
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USA: where is Trump?
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Coronavirus: the brain, a new study
“It costs public money to repair the damage, which could be better spent on vital services”
— Read on www.manchestereveningnews.co.uk/news/greater-manchester-news/council-issues-warning-st-georges-32362644
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British Empire
Ministry of Justice discusses alternative funding options with legal aid lawyers during series of roundtable discussions.
— Read on www.lawgazette.co.uk/news/moj-enters-talks-on-seizing-client-account-interest/5124282.article
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Medicine: diabetes
An Admiral Nurse is a specialist providing life-changing care for families affected by all forms of dementia.
— Read on www.dementiauk.org/information-and-support/how-we-can-support-you/what-is-an-admiral-nurse/
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Israel sexual abuse
grok.com/share/c2hhcmQtMw==_7cf85fb4-7bf0-4e8e-8d3e-4e75f2f2bcf3
The chemical pathway linking inhalation of trichloroethylene (TCE) to the development of Parkinson’s disease (PD) involves exposure, absorption, metabolism, and neurotoxic effects primarily targeting dopaminergic neurons in the substantia nigra pars compacta (SNpc). This connection is supported by epidemiological data, case studies, and animal models showing TCE as an environmental risk factor for PD. Below, I outline the step-by-step pathway based on available evidence.
1. Inhalation and Absorption
• TCE is a volatile organic compound commonly used as an industrial solvent (e.g., for degreasing metals) and found as an environmental contaminant in air, soil, and water. Inhalation is a primary exposure route, especially in occupational settings or through vapor intrusion, where TCE evaporates from contaminated groundwater or soil into indoor air of homes, schools, or workplaces.
• Upon inhalation, TCE rapidly enters the lungs and diffuses into the bloodstream due to its high volatility and lipophilicity. It bypasses first-pass hepatic metabolism to some extent, allowing direct distribution to the brain via perfused blood and potentially olfactory pathways. This enables neurotoxicity at lower doses compared to ingestion.
2. Distribution and Initial Metabolism
• TCE crosses the blood-brain barrier easily because of its fat solubility and accumulates in lipid-rich brain tissues.
• Systemic metabolism occurs mainly in the liver via cytochrome P450 enzymes (primarily CYP2E1), oxidizing TCE to trichloroacetaldehyde (also known as chloral). Chloral is further metabolized to trichloroacetic acid or trichloroethanol, but a portion of chloral can enter the brain unmetabolized or be formed locally.
3. Formation of Key Neurotoxic Metabolite: TaClo
• In the brain, chloral reacts with endogenous tryptamine (a biogenic amine derived from tryptophan metabolism, related to serotonin pathways) through a Pictet-Spengler condensation reaction. This forms the metabolite 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo).
• TaClo is structurally analogous to the neurotoxin MPP+ (the active metabolite of MPTP, a known parkinsonism-inducing compound). This endogenous formation of TaClo is critical, as it amplifies TCE’s toxicity specifically in neural tissues.
4. Cellular and Molecular Neurotoxic Effects
• TaClo selectively targets dopaminergic neurons in the SNpc, inhibiting mitochondrial complex I (part of the electron transport chain). This disrupts ATP production, leading to energy failure and increased production of reactive oxygen species (ROS), causing oxidative stress.
• Oxidative stress triggers a cascade: damage to cellular components (e.g., lipids, proteins, DNA), activation of neuroinflammatory responses (e.g., microglial activation with increased CD68 expression and morphological changes to amoeboid forms), and endolysosomal dysfunction.
• Further effects include phosphorylation and aggregation of α-synuclein (forming Lewy body-like inclusions), a hallmark of PD, and activation of LRRK2 kinase (a protein linked to genetic forms of PD), which impairs vesicular trafficking and exacerbates oxidative stress.
• These processes culminate in apoptosis and degeneration of nigrostriatal dopaminergic neurons, reducing dopamine levels in the striatum (evidenced by decreased tyrosine hydroxylase expression) and causing motor deficits like asymmetric gait impairments.
5. Link to Parkinson’s Disease Development
• Chronic low-dose exposure (e.g., 50–100 ppm in animal models over weeks) recapitulates PD pathology, including 30–50% dopaminergic neuron loss, α-synuclein accumulation, and motor symptoms, with a latency period of 10–40 years in humans before clinical PD emerges.
• Interactions with other factors (e.g., genetic mutations like LRRK2 G2019S or traumatic brain injury) can potentiate effects, worsening mitochondrial dysfunction.
• Epidemiological evidence includes a 500% increased PD risk in TCE-exposed individuals (e.g., from twin studies) and clusters in contaminated sites like Camp Lejeune, where TCE in drinking water (though not inhalation-specific) raised PD risk.
This pathway is not universally present in all exposures, as individual factors like genetics, dose, duration, and co-exposures influence outcomes. TCE’s role in PD is considered preventable, with calls to reduce its use and remediate contaminated sites.
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mRNA excess deaths
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BDS: boycott Puma
North-west firm calls for ministry to be stripped of power to handle negligence claims, comparing its approach to the Post Office.
— Read on www.lawgazette.co.uk/news/solicitor-hits-out-at-mod-for-deny-until-they-die-strategy/5124199.article
Campaigners criticise ‘Orwellian’ use of facial recognition technology
— Read on www.telegraph.co.uk/politics/2025/08/07/police-raid-passport-photo-data-historic-breach-privacy/
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