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Author: Pete's Library
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Your Party finances
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Corbyn recognises Israel
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Starmer and Herzog
seeking the arrest of Israeli President Isaac Herzog for grave breaches of the Geneva Conventions
— Read on www.hindrajabfoundation.org/perpetrators/herzog-complaint-in-uk-police-fail-to-act-and-cps-issues-weak-rejection-on-purported-evidential-grounds
Hi My name is Keith aged 59
i was diagnosed with PD 9 months ago and have been researching the connection with PD and TCE Trycoethelene Decreasing solvents eg Genklene / Inhibisol which i used at Cummins Diesel engines…
— Read on forum.parkinsons.org.uk/t/pd-and-contact-with-tce-genklene-inhibisol/16772
e: Holmes v Poeton Holdings Limited [2023] EWCA Civ 1377
— Read on www.guildhallchambers.co.uk/2023/12/14/case-law-update-holmes-v-poeton-holdings-limited-2023-ewca-civ-1377/
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Man attacked by leopard in Surrey
Understanding and neutralising covid-19 misinformation and disinformation | The BMJ
— Read on www.bmj.com/content/379/bmj-2022-070331
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Censored documents re: Israel WWII
Surgeon carried out amputations but had a secret sexual fetish for body modification.
— Read on www.lawgazette.co.uk/news/former-patients-of-disgraced-amputee-surgeon-demand-clarity/5124371.article
Ahead of the first World Lake Day, which is 27 August, here’s a closer look at the biggest threats to the world’s lakes – and what can be done about them.
— Read on www.unep.org/news-and-stories/story/lakes-around-world-are-decline-heres-why-and-what-can-be-done-about-it
Britain sent over 500 spy flights to Gaza: AOAV study reveals the scale of British intelligence gathering above Gaza, raising fears of complicity in Israeli war crimes
— Read on aoav.org.uk/2025/britain-sent-over-500-spy-flights-to-gaza-aoav-study-reveals-the-scale-of-british-intelligence-gathering-above-gaza-raising-fears-of-complicity-in-israeli-war-crimes/
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USA: where is Trump?
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Coronavirus: the brain, a new study
“It costs public money to repair the damage, which could be better spent on vital services”
— Read on www.manchestereveningnews.co.uk/news/greater-manchester-news/council-issues-warning-st-georges-32362644
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British Empire
Ministry of Justice discusses alternative funding options with legal aid lawyers during series of roundtable discussions.
— Read on www.lawgazette.co.uk/news/moj-enters-talks-on-seizing-client-account-interest/5124282.article
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Medicine: diabetes
An Admiral Nurse is a specialist providing life-changing care for families affected by all forms of dementia.
— Read on www.dementiauk.org/information-and-support/how-we-can-support-you/what-is-an-admiral-nurse/
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Israel sexual abuse
grok.com/share/c2hhcmQtMw==_7cf85fb4-7bf0-4e8e-8d3e-4e75f2f2bcf3
The chemical pathway linking inhalation of trichloroethylene (TCE) to the development of Parkinson’s disease (PD) involves exposure, absorption, metabolism, and neurotoxic effects primarily targeting dopaminergic neurons in the substantia nigra pars compacta (SNpc). This connection is supported by epidemiological data, case studies, and animal models showing TCE as an environmental risk factor for PD. Below, I outline the step-by-step pathway based on available evidence.
1. Inhalation and Absorption
• TCE is a volatile organic compound commonly used as an industrial solvent (e.g., for degreasing metals) and found as an environmental contaminant in air, soil, and water. Inhalation is a primary exposure route, especially in occupational settings or through vapor intrusion, where TCE evaporates from contaminated groundwater or soil into indoor air of homes, schools, or workplaces.
• Upon inhalation, TCE rapidly enters the lungs and diffuses into the bloodstream due to its high volatility and lipophilicity. It bypasses first-pass hepatic metabolism to some extent, allowing direct distribution to the brain via perfused blood and potentially olfactory pathways. This enables neurotoxicity at lower doses compared to ingestion.
2. Distribution and Initial Metabolism
• TCE crosses the blood-brain barrier easily because of its fat solubility and accumulates in lipid-rich brain tissues.
• Systemic metabolism occurs mainly in the liver via cytochrome P450 enzymes (primarily CYP2E1), oxidizing TCE to trichloroacetaldehyde (also known as chloral). Chloral is further metabolized to trichloroacetic acid or trichloroethanol, but a portion of chloral can enter the brain unmetabolized or be formed locally.
3. Formation of Key Neurotoxic Metabolite: TaClo
• In the brain, chloral reacts with endogenous tryptamine (a biogenic amine derived from tryptophan metabolism, related to serotonin pathways) through a Pictet-Spengler condensation reaction. This forms the metabolite 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo).
• TaClo is structurally analogous to the neurotoxin MPP+ (the active metabolite of MPTP, a known parkinsonism-inducing compound). This endogenous formation of TaClo is critical, as it amplifies TCE’s toxicity specifically in neural tissues.
4. Cellular and Molecular Neurotoxic Effects
• TaClo selectively targets dopaminergic neurons in the SNpc, inhibiting mitochondrial complex I (part of the electron transport chain). This disrupts ATP production, leading to energy failure and increased production of reactive oxygen species (ROS), causing oxidative stress.
• Oxidative stress triggers a cascade: damage to cellular components (e.g., lipids, proteins, DNA), activation of neuroinflammatory responses (e.g., microglial activation with increased CD68 expression and morphological changes to amoeboid forms), and endolysosomal dysfunction.
• Further effects include phosphorylation and aggregation of α-synuclein (forming Lewy body-like inclusions), a hallmark of PD, and activation of LRRK2 kinase (a protein linked to genetic forms of PD), which impairs vesicular trafficking and exacerbates oxidative stress.
• These processes culminate in apoptosis and degeneration of nigrostriatal dopaminergic neurons, reducing dopamine levels in the striatum (evidenced by decreased tyrosine hydroxylase expression) and causing motor deficits like asymmetric gait impairments.
5. Link to Parkinson’s Disease Development
• Chronic low-dose exposure (e.g., 50–100 ppm in animal models over weeks) recapitulates PD pathology, including 30–50% dopaminergic neuron loss, α-synuclein accumulation, and motor symptoms, with a latency period of 10–40 years in humans before clinical PD emerges.
• Interactions with other factors (e.g., genetic mutations like LRRK2 G2019S or traumatic brain injury) can potentiate effects, worsening mitochondrial dysfunction.
• Epidemiological evidence includes a 500% increased PD risk in TCE-exposed individuals (e.g., from twin studies) and clusters in contaminated sites like Camp Lejeune, where TCE in drinking water (though not inhalation-specific) raised PD risk.
This pathway is not universally present in all exposures, as individual factors like genetics, dose, duration, and co-exposures influence outcomes. TCE’s role in PD is considered preventable, with calls to reduce its use and remediate contaminated sites.
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mRNA excess deaths
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BDS: boycott Puma
North-west firm calls for ministry to be stripped of power to handle negligence claims, comparing its approach to the Post Office.
— Read on www.lawgazette.co.uk/news/solicitor-hits-out-at-mod-for-deny-until-they-die-strategy/5124199.article
Campaigners criticise ‘Orwellian’ use of facial recognition technology
— Read on www.telegraph.co.uk/politics/2025/08/07/police-raid-passport-photo-data-historic-breach-privacy/
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Politician watch; Lindsay Hoyle;
Your Brain: An Introduction to Its Anatomy
By: Rachel KimballIntroduction:
Your brain is one of those things many of us take for granted. As the site of human consciousness, the coordinator of voluntary movement, and the regulator of nonconscious processes, your ? can do it all. The brain is not just a blob of cells in your skull, and the anatomy of the brain is quite complex. However, it is also very interesting to learn about.
Let’s start with some fun facts about the brain. Did you know…
– The average person has 12,000-60,000 thoughts a day
– The human brain triples in the first year of life and in adulthood, it gets smaller as we get older
– There are no pain receptors in the brain! The pain you feel from headaches are felt by the nerves in your head, face, and neck, NOT the brain. Headaches are triggered by chemical reactions caused by imbalances of neurotransmitters like serotonin, hormone imbalances, and changes in blood vessel constriction and dilation.
– There are one hundred billion neurons in the average brain 75% of the average brain is made of water
Let’s first dive into each lobe of the brain. Each lobe has its own set of distinct functions, and together, the lobes of the brain make you, you. Damage to the brain can result in serious complications, and learning the function/location of each lobe enables us to understand the consequences of brain damage.
Frontal Lobe:Anatomy: The frontal lobes are located directly behind the forehead, and they are the largest lobes in the human brain. Located in the frontal lobe is Broca’s area, which controls the muscles in the mouth used for speech.
Function: The frontal lobe is responsible for speech & language production, motor skills, understanding & reacting to the feelings of others, forming personality, maintaining a sense of motivation, and managing attention.
Damage: The frontal lobes are the most common area for damage in the brain. It can result in paralysis, Broca’s Aphasia (inability to express language,) inability to focus, adynamia (reduced motivation), changes in personality, mood fluctuations, and difficulty controlling impulse.
Parietal Lobe:Anatomy: The parietal lobe is located near the back/top of the head, directly behind the frontal lobe, and separated by the parieto-occipital central sulcus
Function: The parietal lobe is responsible for sensations, such as touch, pressure, pain, heat, and tension, navigating and controlling the body through spatial awareness, understanding written language, and solving math problems
Damage: Damage to the parietal lobe can result in difficulty in distinguishing left from right, spatial disorientation, alexia (problems with reading,) dyscalculia (difficulty with mathematics), and apraxia (difficulty with complex movements).
Occipital Lobe:Anatomy: The occipital lobes are in the rear part of the upper brain. The central cerebral fissure divides the 2 lobes, and the tentorium cerebelli separates them from the temporal lobe and cerebellum. It contains the primary visual cortex, which sends and interprets information through our eyes
Function: The occipital lobe is responsible for depth perception, color determination, distance perception, face recognition, object recognition, and combing the images from both eyes into one image.
Damage: Damage to the occipital lobe can result in blindness and difficulty understanding basic colors & shapes, recognizing familiar faces, detecting moving objects, recognizing words, hallucinations, Riddoch syndrome (can’t see stationary objects,) and epilepsy.
Temporal Lobe:Anatomy: The temporal lobes sit at the bottom middle portion of the brain, just behind the temples. Key structures include the auditory cortex and Wernicke’s area. The auditory cortex performs basic and higher functions of hearing and Wernicke’s area interprets written and spoken speech.
Function: They temporal lobe is responsible for long term memory, emotion, understanding and giving meaning to voices and sounds, and is an essential part of the limbic system.
Damage: Damage to the temporal lobe can result in impaired verbal memory, impaired musical skills, trouble with direction, deafness, auditory hallucination, impaired learning, life-threatening bleeding, dyslexia, Pick’s disease, and aphasia.
Cerebellum:Anatomy: The cerebellum is found at the back & bottom of the brain, right behind the brainstem and under the occipital lobe.
Function: The cerebellum is responsible for maintaining balance, coordinating movement, assisting in vision and coordinates eye movements, motor learning & muscle memory, researchers think the cerebellum has some role in thinking and emotions.
Damage: Damage to the cerebellum can result in lack of muscle control and movement, abnormal eye movements, headaches, slurred speech or difficulty talking, difficulties with walking and mobility, ataxia, and dysmetria (inability to judge distance and know when to stop).
Brainstem:Anatomy: The brainstem is divided into 3 sections: the midbrain (mesencephalon), the pons (metencephalon), and the medulla oblongata (myelencephalon).
Function: The brainstem is responsible for swallowing, breathing, vasomotor control (blood pressure) the senses – taste, smell, hearing, touch, sight, and controlling the heartbeat.
Damage: Damage to the parietal lobe can result in speech disorders,vestibular disturbance, dysphagia (difficulty or pain in swallowing) abnormal consciousness, demyelination (multiple sclerosis),infections, respiratory disturbance, vision problems, problems with other senses, and difficulty with vasomotor control.
Conclusion:
We hope you enjoyed using your brain to learn about your brain! Every part of the brain serves a different purpose which is why it is important for them to work effectively together. Damage to even just one lobe can lead to a decrease in performance and ability to perform certain tasks. We’ll be posting about brain injuries soon, so you can learn about ways to keep your brain safe and healthy.— Read on mapp.mgh.harvard.edu/your-brain-an-introduction-to-its-anatomy/
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Green; snow in Australia
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Public speaking
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Pete's Library 